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Journal of Antimicrobial Chemotherapy (1987) 20, 825-829
© 1987 The British Society for Antimicrobial Chemotherapy

research-article

Reduced virulence in ciprofloxacin-resistant variants of Pseudomonas aeruginosa strains

G. Ravizzola, F. Pirali, A. Paolucci, L. Terlenghi, L. Peroni, A. Colombi and A. Turano

Institute of Microbiology, University of Brescia Spedali Civili, 25100 Brescia, Italy

accepted 27 July 1987

Pseudomonas aeruginosa strains resistant to ciprofloxacin were obtained from parental strains by serial transfer through subinhibitory concentrations of the drug. They showed reduced virulence for mice, and also increased sensitivity to aminoglycosides.


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