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Journal of Antimicrobial Chemotherapy (1987) 20, 735-742
© 1987 The British Society for Antimicrobial Chemotherapy

research-article

Amoxycillin, amoxycillin-clavulanic acid and metronidazole in the treatment of clue cell-positive discharge. A comparative clinical and laboratory study

Willem I. van der Meijdena, Peter Piotb, Suzanne M. Loriauxc and Ernst Stolza

aDepartment of Dermatology and Venereology, University Hospital ‘Dijkzigt’ Rotterdam, The Netherlands bDepartment of Medical Microbiology, Institute of Tropical Medicine Antwerp, Belgium cMedical Department, Beecham Research Laboratories Amstelveen, The Netherlands

accepted 19 May 1987

In an open study, 30 women with clue cell-positive discharge (CCPD) were treated for seven days with either amoxycillin, amoxycillin-clavulanic acid or metronidazole (ten in each group). Patients were monitored on days 2, 4, 9 and 15. Clinical and microscopical parameters were used to assess treatment efficacy. Gas-liquid chromatography of vaginal secretions was also performed. The succinate-lactate ratio had good correlation with the clinical findings. All patients treated with metronidazole were cured by day 4, suggesting that a three-day course is as effective as the standard seven-day regimen. Treatment with amoxycillin-clavulanic acid was less effective resulting in the cure of seven patients by day 15. Amoxycillin established normal secretions in only four patients. Gastro-intestinal complaints, although common in patients treated with amoxycillin-clavulanic acid, were generally mild. We consider amoxycillin-clavulanic acid a possible alternative in the treatment of CCPD.


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