Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Stille, W.
Right arrow Articles by Staib, A. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Stille, W.
Right arrow Articles by Staib, A. H.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Journal of Antimicrobial Chemotherapy (1987) 20, 729-734
© 1987 The British Society for Antimicrobial Chemotherapy

research-article

Decrease of caffeine elimination in man during co-administration of 4-quinolones

Wolfgang Stillea,, Sebastian Harderb, Sylvia Miekeb, Christian Beerb, Pramod M. Shaha, Karin Frecha and A. Horst Staibb

aZentrum der Inneren Medizin, Infektiologie, Klinikum der Johann Wolfgang Goethe-Universität Frankfurt D-6000 Frankfurt 70, Federal Republic of Germany bAbteilung für Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe-Universität Frankfurt D-6000 Frankfurt 70, Federal Republic of Germany

accepted 3 June 1987

Correspondence to: Prof. Dr W. Stille, Zentrum der Inneren Medizin, Infektiologie, Klinikum der Johann Wolfgang Goethe- Universität Frankfurt, Theodor- Stern- Kai 7, D-6000 Frankfurt 70, F.R.G.

The single dose pharmacokinetics of caffeine (220–230 mg per dose) were investigated in 12 healthy male volunteers before and during treatment with ofloxacin (200 mg bd), ciprofloxacin (250 mg bd) and enoxacin (400 mg bd) with a cross-over study design. None of the parameters: mean elimination half-life (T1/2cl), Cmax, total body clearance (Cl{omega}t) and the volume of distribution ({alpha}Vd) of caffeine were noticeably altered by administration of ofloxacin. Striking changes were observed, however, after administration of enoxacin: the T1/2cl was prolonged by as much as 260%, the Cmax increased by 41%; the aVd was reduced by 20% and Cl{omega}t by 78% (mean values). Treatment with ciprofloxacin led to a prolongation of T1/2cl by 15%, to a decrease of aVd by 25% and to a 33% decrease of Cl{omega}t. The results of this intra-individual comparison of caffeine pharmacokinetic data demonstrate that treatment with ciprofloxacin and enoxacin may have a significant inhibitory effect on caffeine elimination.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Antimicrob. Agents Chemother.Home page
H. Kita, H. Matsuo, H. Takanaga, J. Kawakami, K. Yamamoto, T. Iga, M. Naito, T. Tsuruo, A. Asanuma, K. Yanagisawa, et al.
In Vivo and In Vitro Toxicodynamic Analyses of New Quinolone-and Nonsteroidal Anti-Inflammatory Drug-Induced Effects on the Central Nervous System
Antimicrob. Agents Chemother., May 1, 1999; 43(5): 1091 - 1097.
[Abstract] [Full Text]

Home page
 Pharmacol. Rev.Home page
K. Ito, T. Iwatsubo, S. Kanamitsu, K. Ueda, H. Suzuki, and Y. Sugiyama
Prediction of Pharmacokinetic Alterations Caused by Drug-Drug Interactions: Metabolic Interaction in the Liver
Pharmacol. Rev., September 1, 1998; 50(3): 387 - 412.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.