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Journal of Antimicrobial Chemotherapy (1987) 20, 725-728
© 1987 The British Society for Antimicrobial Chemotherapy

research-article

Imipenem kinetics in serum, lung tissue and pericardial fluid in patients undergoing thoracotomy

Giuseppina Benonia, Laura Cuzzolina, Claudio Bertrandb, Vittorio Puchettib and Giampaolo Veloa

aInstitute of Pharmacology and Surgical Clinic, University of Verona Verona, Italy bThoracic Surgery Unit, University of Verona Verona, Italy

accepted 28 May 1987

Imipenem serum pharmacokinetics, lung tissue and pericardial fluid concentrations were measured in 10 patients undergoing thoracotomy, following a 1 g intravenous infusion of imipenem-cilastatin. The serum concentrations of imipenem 0.5 h and 4 h after the end of the 40 min infusion were 53.3 (±16.7) and 2.0 (±0.3) mg/l, respectively. The concentration of imipenem in lung tissue at 1 h was lower than in pericardial fluid and at 2.25 h the mean concentration of imipenem in pericardial fluid was 10.5 mg/l, vs. 0.28 mg/kg of lung tissue. Imipenem concentrations in pericardial fluid remained above 5 mg/l, well above the MIC for most pathogens, for 1 h whereas in pericardial fluid the concentration was 10.5 mg/l at 2.25 h.


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