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Journal of Antimicrobial Chemotherapy (1987) 20, 705-712
© 1987 The British Society for Antimicrobial Chemotherapy

research-article

Comparative efficacy of clindamycin, erythromycin and spiramycin against Staphylococcus aureus in the rat croton oil pouch model

P. G. Daveya,*, N. V Jacobusb and F. P. Tallyb

aDepartment of Clinical Pharmacology, Ninewells Hospital and Medical School Dundee, DD1 9SY, Scotland bDepartment of Clinical Microbiology, Tufts New England Medical Center Boston, MA 02111, U.S.A.

accepted 23 June 1987

*Corresponding author

Spriramycin, a macrolide antibiotic, has inferior in-vitro activity to erythromycin, but superior tissue penetration. Recent publications have suggested that the in-vivo activity of spiramycin should be re-assessed. The efficacy of clindamycin, erythromycin and spiramycin was compared against Staphylococcus aureus infections in the rat croton oil pouch model. The concentration of spiramycin in the pouch fluid was lower than the concentration of clindamycin or erythromycin after single or multiple intraperitoneal injections. In contrast, the concentration of spiramycin in the pouch wall (73.3±14.5 µg/g) was markedly higher than that of erythromycin (< 7.5 µg/g). Multiple doses of spiramycin had no significant effect upon bacterial growth in the pouch, whereas clindamycin and erythromycin had a significant bactericidal effect. The results suggest that spiramycin is bound to tissues, diffuses poorly into tissue fluid and may therefore be ineffective against infections in large collections of tissue fluid.


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