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Journal of Antimicrobial Chemotherapy (1987) 20, 671-675
© 1987 The British Society for Antimicrobial Chemotherapy

research-article

Comparative in-vitro activity of A-56268 (TE-031), a new macrolide antibiotic

G. M. Eliopoulosa,c, E. Reisznera, M. J. Ferrarob,c and R. C. Moelleringa,c

aDepartment of Medicine, New England Deaconess Hospital Boston, Massachusetts 02215, U.S.A. bMassachusetts General Hospital Boston Massachusetts 02215, U.S.A. cHarvard Medical School Boston, Massachusetts 02215, U.S.A.

accepted 22 June 1987

The comparative in-vitro activity of A-56268 (TE-031), a new semisynthetic marcolide antibiotic, was assessed against approximately 400 bacterial isolates. The new drug demonstrated excellent activity against penicillin-susceptible streptococci (MIC90s ≤ 0.06 mg/l) and methicillin-susceptible staphylococci (MIC90 = 0.25 mg/l). Among other Gram-positive organisms tested, a significant number were resistant to A-56268 as well as to erythromycin and clindamycin. A-56268 was at least as active as erythromycin against Pasteurella multocida and Campylobacter jejuni, but was more active than erythromycin against Legionella spp. (MIC90 ≤ 0.06 mg/l), Bacteroides fragilis (MIC90 = 4 mg/l) and Bact. melaninogenicus (MIC90 ≤ 0.125 mg/l). Activity of A-56268 was pH dependent (more active at pH 7 than at pH 6) and was moderately affected by inoculum size. The drug was bactericidal against two strains of Streptococcus pyogenes tested, but exerted a bacteriostatic effect against Staphylococcus aureus and Str. faecalis.


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