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Journal of Antimicrobial Chemotherapy (1987) 20, 595-597
© 1987 The British Society for Antimicrobial Chemotherapy

research-article

Ciprofloxacin treatment of Staphylococcus aureus infections

Julie Righter

Toronto East General and Orthopaedic Hospital and Department of Microbiology, University of Toronto Canada

accepted 11 April 1987

Correspondence to: Dr. J. Righter, Head, Division of Microbiology, Toronto East General and Orthopaedic Hospital, 825 Coxwell Avenue, Toronto, Canada, M4C 3E7

Ciprofloxacin appears to be safe and effective for a wide variety of clinical infections. In-vitro and animal studies point to high cure rates for both methicillin-sensitive and methicillin-resistant Staphylococcus aureus infections. Seventeen patients with staphylococcal infections severe enough to require hospital admission and initial parenteral therapy were treated with ciprofloxacin; the results were poor, with clinical failure in five and bacteriological failure in 12. All pathogens isolated were susceptible to ciprofloxacin both before and after therapy and tolerance was not detected. Further study is required before ciprofloxacin can be recommended for life threatening staphylococcal infections.


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