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Journal of Antimicrobial Chemotherapy (1987) 20, 585-594
© 1987 The British Society for Antimicrobial Chemotherapy

research-article

The efficacy and safety of ciprofloxacin and ofloxacin in chronic Pseudomonas aeruginosa infection in cystic fibrosis

Tim Jensena,, Svend Stenvang Pedersenb, Claus Henrik Nielsenc, Niels Heibyb and Christian Kocha

aDepartment of Paediatrics Rigshospitalet, Copenhagen, Denmark bStatens Seruminstitut, Department of Clinical Microbiology Rigshospitalet, Copenhagen, Denmark cDepartment of Ophthalmology Rigshospitalet, Copenhagen, Denmark

accepted 11 April 1987

Correspondence to: Dr Tim Jensen, Dept. of Clinical Microbiology, Afsnit 7806, Rigshospitalet, Tagensvej 20, DK-2200 Copenhagen N, Denmark

The clinical efficacy and safety of ciprofloxacin and ofloxacin were compared in a prospective, randomized double blind, placebo combined cross-over study in 26 adult cystic fibrosis patients with chronic broncho-pulmonary Pseudomonas aeruginosa infection. Active treatment consisted of ciprofloxacin 750 mg orally twice daily or ofloxacin 400 mg orally twice daily; both treatments were given for 14 days, with three months between treatment periods; 21 patients completed both treatment periods. Treatment with both ciprofloxacin and ofloxacin was associated with a good clinical response as judged by clinical score, lung function tests and inflammatory parameters; no difference between ciprofloxacin and ofloxacin was found. Adverse reactions were seen in nine of 24 patients who received ciprofloxacin and in six of 23 who received ofloxacin. The majority were dyspeptic reactions or photosensitivity. No serious adverse reactions occurred. Three cases of treatment failure were found, one of which was associated with development of resistant P. aeruginosa during ofloxacin treatment. The mean MIC of both drugs increased during treatment but returned to pretreatment values within three months. Ciprofloxacin and ofloxacin seem to be valuable agents for intermittent treatment of chronic P. aeruginosa lung infection in adult cystic fibrosis patients.


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