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Journal of Antimicrobial Chemotherapy (1987) 20, 575-583
© 1987 The British Society for Antimicrobial Chemotherapy

research-article

Comparative pharmacokinetics of ciprofloxacin and ofloxacin in cystic fibrosis patients

Svend Stenvang Pedersena,, Tim Jensenb and Eigill F. Hvidbergc

aStatens Seruminstitut, Department of Clinical Microbiology Rigshospitalet, Copenhagen, Denmark bDepartment of Paediatrics Rigshospitalet, Copenhagen, Denmark cDepartment of Clinical Pharmacology Rigshospitalet, Copenhagen, Denmark

accepted 16 May 1987

Correspondence to: Dr Svend Stenvang Pedersen, Dept. of Clinical Microbiology, afsn. 8223 Rigshospitalet, Juliane Mariesvej 28.2. DK-2100 Copenhagen Ø, Denmark

The steady state pharmacokinetic properties of ciprofloxacin and ofloxacin were compared in cystic fibrosis patients. In a cross-over study eighteen adult patients with chronic Pseudomonas aeruginosa lung infection were given either oral ciprofloxacin 750 mg bid or oral ofloxacin 400 mg bid for two weeks. Three months later the alternative treatment was given. Concentrations were determined by a microbiological assay. Mean serum concentrations of ofloxacin (peak 5.9 mg/l) were higher than for ciprofloxacin (peak 4.0 mg/l). The time to reach maximal concentrations did not differ. The apparent total body clearance was significantly greater for ciprofloxacin, but renal clearances were similar. Relative to ofloxacin ciprofloxacin had a significantly shorter serum elimination half-life (3.4 vs. 6.4 h), showed less penetration into sputum (18% vs. 79%) and a lesser amount was recovered in urine (21 % vs. 71% up to 12 h after dosing). No correlation was found between any pharmacokinetic parameter and change in pulmonary function.


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