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Journal of Antimicrobial Chemotherapy (1987) 20, 537-540
© 1987 The British Society for Antimicrobial Chemotherapy

research-article

Laboratory evaluation of topically used antibiotics: framycetin MIC and extinction time data for Pseudomonas aeruginosa

B. D. Rawal

Pharmaceutical Microbiology, Pharmacy Department, University of Queensland St. Lucia. Australia 4067

accepted 16 May 1987

Minimum inhibitory concentration (MIC) and extinction time (ET) of framycetin (0.5% in isotonic buffer) were determined. Of 90 consecutive clinical isolates of Pseudomonas aeruginosa, obtained from patients with ear or eye infections, 88.9% were inhibited by 62.5 mg/l and 96.66% were killed within 60 min by framycetin (0.5%). Determination of ET appears to be a promising technique for quantifying the bacterial action of high drug concentrations. Further clinical and experimental studies are required to see whether the ET predicts the efficacy of topical antibacterial preparations better than the MIC.


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