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Journal of Antimicrobial Chemotherapy (1987) 20, 519-522
© 1987 The British Society for Antimicrobial Chemotherapy

research-article

Effect of D-propanolol on growth and motility of flagellate protozoa

M. J. G. Farthing, P. M. G. Inge and R. M. Pearsona

Department of Gastroenterology, St. Bartholomew's Hospital London EC1 A 7BE, U.K. aClinical Pharmacology, St. Bartholomew's Hospital London EC1 A 7 BE, U.K.

accepted 14 April 1987

Propranolol inhibits sperm motility and has been considered as a spermicide contraceptive. In view of the inhibitory effects of D-propranolol on sperm flagellar activity, we have investigated its effect on motility and growth of two human flagellate, protozoan parasites. D-propranolol had a dose-dependant inhibitory effect on motility of Giardia lamblia and Trichomonas vaginalis with ED50S of 0.38 and 0.66 mmol/l respectively. D-propranolol also inhibited growth of both parasites with ED50S of 0.18 and 0.23 mmol/l for Giardia and Trichomonas respectively. D-propranolol, unlike DL-propranolol is devoid of the unwanted effects of beta-blockade, and thus may be a useful antiprotozoal drug particularly after vaginal placement when it is concentrated in vaginal mucus.


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