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Journal of Antimicrobial Chemotherapy (1987) 20, 497-503
© 1987 The British Society for Antimicrobial Chemotherapy

research-article

In-vitro activity of LY146032 against Gram-positive isolates from cancer patients

Hiroshi Saito, Kenneth V. I. Rolston*, Dah Hsi Ho, Barbara LeBlanc and Gerald P. Bodey

Section of Infectious Diseases, Department of Medical Specialties. The University of Texas M. D. Anderson Hospital and Tumor Institute 1515 Holcombe Boulevard, Houston, Texas 77030. U.S.A.

accepted 1 April 1987

*Correspondence to: Kenneth V. I. Rolston, Infectious Diseases—47, M. D. Anderson Hospital, 6723 Bertner Avenue, Houston, Texas 77030, U.S.A.

The in-vitro activity of LY146032 was compared with that of other antibiotics against Gram-positive organisms, mostly isolated from cancer patients. LY 146032 inhibited all isolates, including methicillin-resistant Staphylococcus aureus and Streptococcus faecalis, at a concentration of ≤2.0 mg/l. The MBCs of this new drug were within eight times the MICs for all bacteria tested.


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