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Journal of Antimicrobial Chemotherapy (1987) 20, 405-411
© 1987 The British Society for Antimicrobial Chemotherapy

research-article

Antitrichomonal activity of {alpha}-difluoromethylornithine

Alison F. Bremnera, Graham H. Coombsa and Michael J. Northb

aDepartment of Zoology, University of Glasgow Glasgow, G12 8QQ bDepartment of Biological Science, University of Stirling Stirling, FK9 4LA, Scotland

Received 10 March 1987;

{alpha}-Difluoromethylornithine, an inhibitor of polyamine biosynthesis, affected the pathogenicity of Trichomonas vaginalis in two model systems. Firstly, it blocked the cytotoxic effect of the parasite towards mammalian cells in culture: at a concentration of 1 mM it prevented the death of mouse myeloma cells in mixed culture with trichomonads. Secondly, when administered orally to mice (multiple doses of 750 mg/kg body wt), the drug delayed the development of subcutaneous abscesses due to T.vaginalis infection. The same drug dose did not cure intravaginal infections by the parasite. The implications of these findings with respect to the value of the model systems used and the potential of DFMO as an antitrichomonal drug are discussed.


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