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Journal of Antimicrobial Chemotherapy (1987) 20, 399-404
© 1987 The British Society for Antimicrobial Chemotherapy

research-article

Influence of various antibiotics on phagocytosis of Staphylococcus aureus by human polymorphonuclear leucocytes

P. Van der Auwera, M. Husson and J. Frühlinga

Service de Médecine et Laboratoire d'Investigation Clinique H. J. Tagnon rue Héger-Bordet, 1, B-1000 Brussels, Belgium aService de Radiothérapie et de Médecine Nucléaire, Institut Jules Bordet, Centre des Tumeurs de l'Université Libre de Bruxelles rue Héger-Bordet, 1, B-1000 Brussels, Belgium

Received 19 March 1987;

The influence of several new antibiotics on phagocytosis of two strains of Staphylococcus aureus by human polymorphonuclear leucocytes was studied with a radioisotopic method. The following antibiotics were tested in concentrations obtained in the serum after standard administration: gentamicin, netilmicin, amikacin, oxacillin, clindamycin, vancomycin, teicoplanin, rifampicin, ansamycin, coumermycin, enoxacin, ciprofloxacin, two new fluoro-quinolones CI 934 and RO 236240, and LY 146032 a new lipopeptidic antibiotic. Among them, only coumermycin significantly decreased phagocytosis, this was dependent on concentration, strain and source of the polymorphonuclear leucocytes.


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