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Journal of Antimicrobial Chemotherapy (1987) 20, 379-382
© 1987 The British Society for Antimicrobial Chemotherapy

research-article

The in-vitro activity of doxycycline and minocycline against anaerobic bacteria

M. Robbins, R. Marais, D. Felmingham and G. L. Ridgway

Department of Clinical Microbiology, University College Hospital London, UK

Received 24 March 1987;

Correspondence to: Mr.D. Felmingham, Department of Clinical Microbiology, University College Hospital, Grafton Way, London WCIE 6AU, UK

The likelihood of bacterial resistance now prevents the use of oxytetracycline in the empirical therapy of anaerobic infections. This study investigates the in-vitro activity of two semi-synthetic derivatives, doxycycline and minocycline, against a range of anaerobic bacteria. MICs for each antibiotic were determined by an agar incorporation technique. Doxycycline and minocycline were four to eight times more active against the majority of strains than oxytetracycline. With the exception of Bacteroides bivius, almost 90% of strains were inhibited by 4 mg/l of doxycycline or minocycline, but resistance to the same concentration of oxytetracycline was present in 60% of the B.fragilis group, 30% of Peptostreptococcusspp. and 24% of Clostridium perfringens. Doxycycline and minocycline represent an alternative therapy for anaerobic infections where bacterial sensitivities are known.


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