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Journal of Antimicrobial Chemotherapy (1987) 20, 223-231
© 1987 The British Society for Antimicrobial Chemotherapy

research-article

In-vitro studies of antibiotic combinations for multiply-resistant coagolase-negative staphylococci

Richard A. Proctora, Penny Wickb, Richard J. Hamillc, Patricia Horstmeierd, Jo Gullings-Handleyb, Marcia Weisenseld and Glennda Brandtd

aDepartments of Medical Microbiology and Medicine, University of Wisconsin Medical School Madison, Wisconsin 53706 bHygiene Laboratory Stovall Building, Madison, Wisconsin 53706 cV. A. Medical Center, Baylor University Houston, Texas 77211 dClinical Microbiology Laboratory, Clinical Sciences Center Madison, Wisconsin 53792, U.S.A.

Coagulase-negative staphylococci are being implicated as pathogens with increasing frequency and this may in part be due to their development of resistance to a wide variety of antibiotics. Because vancomycin is the only drug generally available for treating these multiply resistant organisms, we have tested several combinations of antibiotics for activity in vitro against these organisms. These in-vitro studies suggested that rifampicin combined with either gentamicin or cefamandole might occasionally provide an efficacious alternative to vancomycin, while the novobiocin plus rifampicin combination might be an effective oral regimen against methicillin-resistant coagulase negative staphylococci. Resistance to co-trimoxazole was found in nearly all isolates tested.


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