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Journal of Antimicrobial Chemotherapy (1987) 20, 47-55
© 1987 The British Society for Antimicrobial Chemotherapy

research-article

Suppression of penicillin-induced bacteriolysis of staphylococci by some anticoagulants

J. Weckea, E. Kwaa, M. Lahavb, I. Ginsburgb and P. Giesbrechta

aRobert Koch-Institut des Bundesgesundheitsamtes Nordufer 20, D-1000 Berlin 65, Germany bThe Hebrew University, Hadassah Faculty of Dental Medicine en Karem, PO Box No. 1172, Jerusalem, Israel

accepted 20 February 1987

Heparinoids and related negatively-charged substances caused suppression of the penicillin-induced bacteriolysis of staphylococci and a higher viability rate. Furthermore, the penicillin-induced release of cell wall material was reduced by these substances. The main reason for this suppression of bacteriolysis was an inhibition of the activity of cell wall autolytic enzymes while the penicillin-specific perturbations of wall morphogenesis were not affected.


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