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Journal of Antimicrobial Chemotherapy (1987) 20, 133-136
© 1987 The British Society for Antimicrobial Chemotherapy

research-article

Studies on a new formulation of ceftazidime—ceftazidime arginine—in patients with recurrent chest infections

B. I. Daviesa, F. P. V. Maesen, C. Baur and W. B. M. Evers

aDepartment of Medical Microbiology De Wever Ziekenhuis, Heerlen, The Netherlands Department of Respiratory Diseases De Wever Ziekenhuis, Heerlen, The Netherlands

accepted 2 January 1987

One hundred hospital patients with respiratory infections were treated with 1 or 2 g intramuscular injections of ceftazidime sodium or of a new formulation of ceftazidime with arginine three times daily. Clinical and microbiological assessments showed no significant differences in efficacy between the two preparations. Local pain necessitating lignocaine was noted in five of 49 evaluable patients given ceftazidime sodium (10.2%) but in none of the 50 receiving ceftazidime arginine. No other unwanted effects were recorded. The pharmacokinetic results after the 1 g injections showed slightly higher Cmax values with ceftazidime arginine with correspondingly greater 0–7 h AUC values. The mean AUCs were almost identical after the 2 g injections.


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