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Journal of Antimicrobial Chemotherapy (1987) 19, 823-829
© 1987 The British Society for Antimicrobial Chemotherapy

research-article

Bilirubin displacement by ceftriaxone in neonates: evaluation by determination of ‘free’ bilirubin and erythrocyte-bound bilirubin

Jean-Marc Guliana,b,, Véronique Gonardb, Christiane Dalmassoa and Christian Palixc

a Laboratoire de Chimie Biologique, Faculté de Médecine 27 Bd Jean Moulin, 13385 Marseille Cédex 5 b Laboratoire de Biochimie, CHU Timone 27 Bd Jean Moulin, 13385 Marseille Cédex 5 c Service de Clinique Médicale Infantile CHU Timone, 27 Bd Jean Moulin, 13385 Marseille Cédex 5, France

* Reprint requests to: Dr J.-M. Gulian, Laboratoire de Chimie Biologique Faculté de Médecine, 27 Bd Jean Moulin, 13385 Marseille Cédex 5, France.

Determination of ‘free’ bilirubin, erythrocyte-bound bilirubin and unconjugated bilirubin was used to test the effects of ceftriaxone on the binding of bilirubin to albumin. This study, performed on blood samples from icteric neonates, showed that the addition of ceftriaxone produced an increase of free bilirubin and erythrocyte-bound bilirubin and a decrease of unconjugated bilirubin. Ceftriaxone displays a significant displacing effect at concentrations obtained during therapeutic use and should be used with caution in high-risk jaundiced infants.


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