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Journal of Antimicrobial Chemotherapy (1987) 19, 791-793
© 1987 The British Society for Antimicrobial Chemotherapy

research-article

Bacampicillin and the immune response

A. Scordamaglia, G. Ciprandi, S. Mirabellia, R. Aquilinaa, L. Calcagnob, A. Nicolinib, C. Simonassic and M. De Palmac

Allergy Center & Semeiotica Med. RR, Internal Medicine Scientific Institute, Genoa University Imperia a Pneumology Dept., Costarainera Hospital, III USL Imperia b Pneumology Dept., Chiavari Hospital, XVII USL Chiavari cBronchology Dept., San Martino Hospital, XIII USL Genoa, Italy

accepted 30 November 1986

Antonio Scordamaglia, M.D., I.S.M.I.-Universita di Genova, Viale Benedetto XV, 6 16132 Genova, Italy.

To evaluate the possible influence of a bacampicillin on the immune response, 16 subjects, out of a group of 60 patients with bacterial respiratory tract infections, had various tests of immune function determined, before and after treatment. The peripheral mononuclear blastogenic index (ratio between PHA-induced and spontaneous proliferation), PHA-induced interferon-gamma production, percentages of T and B lymphocytes, serum immunoglobulins (IgG, IgM, IgA) levels, failed to show any significative differences before and after the treatment with bacampicillin. The PHA-induced interleukin-2 production increased after treatment but just failed to reach statistical significance (0.1 < P < 0.05; t = 1.9). The clinical condition of 56 of the sixty (93.3%) treated patients improved and neither side-effects nor alterations of liver or kidney function were observed. This study has shown no inhibitory effect of bacampicillin on the immune response while confirming its clinical efficacy.


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