Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (41)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Roche, Y.
Right arrow Articles by Pocidalo, J.-J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Roche, Y.
Right arrow Articles by Pocidalo, J.-J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Journal of Antimicrobial Chemotherapy (1987) 19, 781-790
© 1987 The British Society for Antimicrobial Chemotherapy

research-article

Comparative effects of quinolones on human mononuclear leucocyte functions

Yvon Rochea, Marie-Anne Gougerot-Pocidalob,, Michele Fayb, Daniel Etiennea, Nadine Foresta and Jean-Jacques Pocidaloc

a Laboratoire de Biologie-Odontologie, Université Paris 7, 2 Place Jussieu, 75251 Paris Cédex 05 b Inserm U. 294, Chu Bichat, Université Paris 7 75877 Paris Cédex 18 c Inserm U. 13 et Département de Pharmacologie Clinique, Hôpital Claude Bernard 75944 Paris Cédex 19, France

accepted 3 December 1986

M. A. Gougerot-Pocidalo, Laboratoire d‘Immunologie et d’Hematologie, Chu Bichat, 46 rue Henri Huchard 75877 Paris Cedex 18, France.

The effects of three quinoline derivatives-pefloxacin, ciprofloxacin and ofloxacin— were investigated in mitogen-stimulated human peripheral blood mononuclear leucocytes (MNL).

At concentrations of 50 mg/1 or more, pefloxacin, ciprofloxacin or ofloxacin significantly inhibited MNL proliferation in response to phytohaemagglutinin. This inhibition was more marked with ciprofloxacin than pefloxacin or ofloxacin.

To determine the possible mechanism(s) involved in the inhibition of MNL proliferation following exposure to pefloxacin, ciprofloxacin or ofloxacin, we assessed (1) interleukin-1 (IL-1) activity in supernatants from monocytes treated with the quinolones and (2) the effects of 2-mercaptoethanol (2-ME) a thiol compound which acts as an antioxidant agent and the effect of indomethacin (INDO) an inhibitor of prostaglandin E2 synthesis. 2-ME and INDO did not prevent the decrease in the proliferation. IL-1 activity was shown to be decreased for the same range of antibiotic concentrations as observed for the inhibition of MNL proliferation.

Cellular viability of the MNL or monocytes was not modified by any of the quinolones at the concentrations tested.

Taken together, these results suggest that pefloxacin, ciprofloxacin and ofloxacin act as immunomodulators. The mechanism involved with the cascade of events that leads to the lymphocyte proliferation and the clinical relevance need further investigation.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Antimicrob. Agents Chemother.Home page
S. M. Uriarte, R. E. Molestina, R. D. Miller, J. Bernabo, A. Farinati, K. Eiguchi, J. A. Ramirez, and J. T. Summersgill
Effects of Fluoroquinolones on the Migration of Human Phagocytes through Chlamydia pneumoniae-Infected and Tumor Necrosis Factor Alpha-Stimulated Endothelial Cells
Antimicrob. Agents Chemother., July 1, 2004; 48(7): 2538 - 2543.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
N. Hirata, K. Hiramatsu, K. Kishi, T. Yamasaki, T. Ichimiya, and M. Nasu
Pretreatment of Mice with Clindamycin Improves Survival of Endotoxic Shock by Modulating the Release of Inflammatory Cytokines
Antimicrob. Agents Chemother., September 1, 2001; 45(9): 2638 - 2642.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
A. A. Khan, T. R. Slifer, and J. S. Remington
Effect of Trovafloxacin on Production of Cytokines by Human Monocytes
Antimicrob. Agents Chemother., July 1, 1998; 42(7): 1713 - 1717.
[Abstract] [Full Text]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.