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Journal of Antimicrobial Chemotherapy (1987) 19, 767-770
© 1987 The British Society for Antimicrobial Chemotherapy


research-article

Activities of metronidazole and niridazole against Trichomonas vaginalis clinical isolates

N. Yarletta,*, H. Hofb and N. C. Yarletta,{dagger}

aDepartment of Microbiology, University College Cardiff CF2 ITA, Wales bInstitute of Hygiene and Microbiology, Bayerische Julius-Maximilians Universität Würzburg, Federal Republic of Germany

accepted 11 December 1986


{dagger}The Rockefeller University, 120 York Avenue, New York NY 10021, U.S.A.

The activities of niridazole and metronidazole against Trichomonas vaginalis ClNIH and six isolates of clinical origin were compared using the in-vitro assay technique. Under the standard anaerobic assay conditions both metronidazole and niridazole were highly effective at low concentrations against all the strains used. However niridazole, in contrast to metronidazole, was equally effective in the aerobic assay, a feature which may be exploited in the chemotherapy of patients with refractory trichomoniasis.


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