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Journal of Antimicrobial Chemotherapy (1986) 18, 271-276
© 1986 The British Society for Antimicrobial Chemotherapy

research-article

Synergy of amoxycillin combined with clavulanate and YTR 830 in experimental infections in mice

Stephen C. Aronoff*,{ddagger},, Michael R. Jacobs{dagger}, Pauline H. Labrozzi* and Shigeru Yamabe§

*Departments of Pediatrics, Case-Western Reserve University School of Medicine Cleveland, Ohio, U.S.A. {dagger}Departments of Pathology, Case-Western Reserve University School of Medicine Cleveland, Ohio, U.S.A. {ddagger}Division of Pediatric Infectious Diseases, Rainbow Babies and Children's Hospital Cleveland, Ohio, U.S.A. §Division of Chemotherapy, Kobe College Research Institute Nishinomiya, Japan

accepted 3 February 1986

Correspondence to: Stephen C. Aronoff, M. D.; Division of Pediatric Infectious Diseases, Rainbow Babies and Children's Hospital, 2101 Adelbert Road, Cleveland, Ohio, U.S.A.

YTR 830, a new ß-lactamase inhibitor, is synergistic with amoxycillin in vitro against a number of ß-lactamase-producing organisms. The combination of amoxycillinYTR 830 was compared to amoxycillin-clavulanate in the treatment of experimental Staphylococcus aureus, Citrobacter freundii and Proteus mirabilis infections in mice. Both combinations were synergistic with amoxycillin against all three test organisms. The amoxycillin-clavulanate combination was superior against S. aureus and C. freundii while amoxycillin-YTR 830 was more effective against P. mirabilis. The difference in efficacy between the two drug combinations appears to relate to the degree of protection afforded the animals by the ß-lactamase inhibitor alone. YTR 830 is a promising new agent and should undergo further investigation.


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