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Journal of Antimicrobial Chemotherapy (1986) 18, 251-260
© 1986 The British Society for Antimicrobial Chemotherapy

research-article

The antimicrobial activity of ciprofloxacin against Legionella species and the treatment of experimental Legionella pneumonia in guinea pigs

Atsushi Saito, Hironobu Koga, Hideaki Shigeno, Koichi Watanabe, Kenji Mori, Shigeru Kohno, Yoshiteru Shigeno, Yoji Suzuyama, Keizo Yamaguchi, Masaki Hirota and Kohel Hara

The 2nd Department of Internal Medicine, Nagasaki University, School of Medicine Nagasaki 852, Japan

accepted 17 January 1986

The antimicrobial activity of ciprofloxacin was tested against 15 standard reference strains, and 37 clinical and environmental strains of Legionella pneumophila by an agar dilution method, using a new growth medium (B-SYE agar) which we devised.

The minimal inhibitory concentrations of ciprofloxacin were found to be inoculum dependent, and ranged from 0.02 to 0.06mg/1 at 106 cfu inoculum and 0.02 to 0.125 mg/1 at 104 cfu inoculum. The most potent antibacterial activity was shown by rifampicin, followed by ofloxacin, ciprofloxacin, enoxacin, norfloxacin, erythromycin and pipemidic acid in that order.

The therapeutic efficacy of ciprofloxacin in experimental guinea pig pneumonia due to L. pneumophila was fairly good with a survival rate of 80%. From other data of ours, its effectiveness in experimental pneumonia was equal to or greater than that of erythromycin. Further studies would be appropriate to investigate the possibility of using ciprofloxacin for the treatment of human L. pneumophila infection.


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