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Journal of Antimicrobial Chemotherapy (1986) 18, 233-237
© 1986 The British Society for Antimicrobial Chemotherapy

research-article

Effects of cefotaxime and cefodizime on human granulocyte functions in vitro

M. T. Labro, C. Babin-Chevaye and J. Hakim

INSERM U. 294 and Laboratoire d'Hematologie et d'Immunologie, Centre Hospitalo-Universitaire Xavier Bichat 46, rue Henri Huchard, 75018 Paris, France

accepted 10 January 1986

In vitro, cefotaxime and cefodizime enhanced significantly the bactericidal activity of human neutrophils against Staphylococcus aureusP 209 A, but not phagocytosis. The increase was about 150% for cefotaxime and 400% for cefodizime at concentrations as low as 1 mg/1. Furthermore, by two different techniques (NBT and cytochrome C reduction tests) cefotaxime but not cefodizime significantly enhanced superoxide anion production by zymosan-stimulated neutrophils. Other neutrophil functions (chemotaxis and myeloperoxidase-mediated iodination of proteins) were not significantly altered by either antibiotic, even at concentrations as high as 1000 mg/1.


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