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Journal of Antimicrobial Chemotherapy (1986) 18, 171-175
© 1986 The British Society for Antimicrobial Chemotherapy

research-article

In-vitro activity of coumermycin against methicillin-resistant staphylococci: a comparison with six other agents

Mark G. Thomas and Selwyn D. R. Lang

Middlemore Hospital Auckland, New Zealand

accepted 7 January 1986

Correspondence: Dr M. G. Thomas, St Georges Hospital Medical School, Department of Communicable Diseases, Jenner Wing, Cranmer Terrace, London SW 17 ORE.

The in-vitro activity of coumermycin was compared with that of vancomycin, rifampicin, fusidic acid, trimethoprim-sulphamethoxazole, norfloxacin and cefamandole against seven isolates of methicillin-resistant Staphylococcus aureus and 97 isolates of methicillin-resistant coagulase negative staphylococci. Apart from one strain of methicillin-resistant S. aureus all isolates were inhibited by ≤0.06 mg/l of coumermycin. Cefamandole was more active against strains of S. epidermidis than against other coagulase negative staphylococci.


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