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Journal of Antimicrobial Chemotherapy (1986) 17, 481-487
© 1986 The British Society for Antimicrobial Chemotherapy

research-article

The neutralization of antibiotic action by metallic cations and iron chelators

A. A. Miles and J. P. Maskell

Department of Medical Microbiology, The London Hospital Medical College London El, England

accepted 6 November 1985

The neutralization of the action of a variety of antibiotics on klebsiellae by moderate doses of di- and tri-valent metallic cations, was measured in vitro. Some ß-lactams tested were affected by Mg++ and by Cu++. Of six tetracyclines one was moderately neutralized by Ca++, two by Mg++, three by Cu++, and all, strongly, by Fe+++. Erythromycin was affected by Ca++, lincomycin by Ca++, Mg++ and Cu++. Aminoglycosides were affected by Ca++ and Mg++ and strongly by Fe+++.

Five antibiotics (three ß-lactams and two macrolides) with high MICs for klebsiellae were tested against staphylococci: most of the reversing agents were ineffective.

The microbial iron chelators, desferrioxamine and enterochelin were largely inactive, affecting only two aminoglycosides.


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