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Journal of Antimicrobial Chemotherapy (1986) 17, 459-461
© 1986 The British Society for Antimicrobial Chemotherapy

research-article

In-vitro activity of ciprofloxacin, ceftriaxone and five other antimicrobial agents against 95 strains of Brucella melitensis

J. Bosch, J. Linares, M. J. López de Goicoechea, J. Ariza, M. C. Cisnal and R. Martin

Servicio de Microbiología, Hospital de Bellvitge ‘Princeps d'Espanya’, L'Hospitalet de Llobregat Barcelona, Spain

accepted 4 November 1985

We studied the in-vitro activity of seven antibiotics against 95 strains of Brucella melitensis isolated in blood cultures of 95 patients with brucellosis. The minimum inhibitory concentration (MIC) was measured by the agar dilution method.

All strains of B. melitensis were inhibited by doxycycline at 0.25 mg/l, tetracycline at 0.5 mg/l, ciprofloxacin at 0.5 mg/l, streptomycin at 1mg/l, ceftriaxone at 1 mg/l, rifampicin at 4 mg/l and by co-trimoxazole at 0.5/9.5 mg/l.

We did not find strains resistant to any of the antibiotics studied. All antibiotics, including ciprofloxacin and ceftriaxone, showed a good in-vitro activity against B. melitensis.


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