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Journal of Antimicrobial Chemotherapy (1986) 17, 221-226
© 1986 The British Society for Antimicrobial Chemotherapy

research-article

Activity of penicillin or ticarcillin in combination with clavulanic add in the treatment of experimental intra-abdominal abscess

Madhu B. Bansal, R. Prabahala and Haragopal Thadepalli

Division of Infectious Diseases, Department of Internal Medicine and Pathology, Charles R. Drew Postgraduate Medical School and UCLA School of Medicine Los Angeles, California, U.S.A

accepted 11 July 1985

The combination of clavulanic acid (CA) with penicillin or ticarcillin was evaluted in a rat intra-abdominal abscess model. Gelatin capsules filled with a mixture of Bacteroides fragilis and Escherichia coli were implanted intraperitoneally in male Wistar rats. Four different groups of animals with appropriate controls were treated with penicillin or ticarcillin alone or in combination with CA. The treatment was started either immediately or delayed for 48 h after peritoneal inoculation. The therapeutic regimen was given for ten days at 8-hourly intervals. The mortality rate decreased to almost one-half when antibiotic therapy was started within 6 h. Seventy-nine to 89% of animals were cured when treated with ticarcillin in combination with CA showing that ticarcillin + CA was the most effective regimen of those tested in the treatment of experimental intra-abdominal abscess of rats caused by Bact. fragilis and E. coli.


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