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Journal of Antimicrobial Chemotherapy (1985) 16, 475-484
© 1985 The British Society for Antimicrobial Chemotherapy

research-article

Antibacterial activity of ofloxacin and other 4-quinolone derivatives: in-vitro and in-vivo comparison

J. F. Chantot and A. Bryskier

Centre de Recherches Roussel UCLAF 102, Route de Noisy, 93230 Romainville, France

accepted 17 April 1985

Ofloxacin (DL8280, RU43280) is a newly introduced oxazine quinolone derivative with broad and potent antibacterial activity. Ofloxacin showed excellent in-vitro activity against Enterobacteriaceae while most strains of Pseudomonas aeruginosa were inhibited by less than 2mg/l. The compound was significantly more potent than norfloxacin against Acinetobacter spp. and Staphylococcus spp.

Ofloxacin and norfloxacin behaved similarly with respect to inoculum size, effect of urine and serum, bactericidal properties and frequency of spontaneous resistant mutants.

Ofloxacin displayed an in-vivo antibacterial activity up to five times greater than that of pefloxacin and norfloxacin, probably due to the conjunction of favourable pharmacokinetics, excellent bacterial susceptibility and good stability towards metabolic degradation.


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