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Journal of Antimicrobial Chemotherapy (1985) 16, 469-473
© 1985 The British Society for Antimicrobial Chemotherapy

research-article

In-vitro activity of Ro-15-8074, a new oral cephalosporin

Martine Peeters and Peter Piot

Department of Microbiology, Institute of Tropical Medicine Nationalestraat 155, B-2000 Antwerpen, Belgium

accepted 17 April 1985

The in-vitro activity of Ro-15-8074, a new oral cephalosporin, was tested against common clinical isolates, and compared with the in-vitro activity of cefaclor, cefadroxil, ampicillin and co-trimoxazole. Its activity against Enterobacteriaceae was better than those of the other antibiotics tested. It was also highly active against Haemophilus influenzae, including ß-lactamase producing strains.

Its activity against Pseudomonas aeruginosa and Acinetobacter spp., was poor. Ro-15-8074 was less active against staphylococci and group D streptococci than were cefaclor, cefadroxil and ampicillin. It was equally or less active than cefaclor, cefadroxil, ampicillin and co-trimoxazole against other streptococci.


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