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Journal of Antimicrobial Chemotherapy (1985) 16, 463-468
© 1985 The British Society for Antimicrobial Chemotherapy

research-article

In-vitro activity of BMY 28142, a new aminothiazolyl cephalosporin

John C. H. Steele, Jr.*, Barbara H. Edwards* and J. Peter Rissing{dagger}

*Clinical Microbiology Laboratory, Department of Pathology, Medical College of Georgia Augusta, Georgia 30912 {dagger}Department of Medicine, Veterans Administration Medical Center and Medical College of Georgia Augusta, Georgia 30910, U.S.A.

accepted 17 April 1985

The in-vitro activity of BMY 28142, a new {alpha}-methoxyimino aminothiazolyl cephalosporin, was determined by microdilution broth techniques. The agent demonstrated excellent activity against recent clinical Enterobacteriaceae isolates with a 90% minimum inhibitory concentration (MIC90) of 0·25 mg/l or less for all but one species tested. BMY 28142 inhibited all Pseudomonas aeruginosa strains tested (MIC90=8·0 mg/l) as well as most other non-fermentative bacteria studied. Methicillin-susceptible Staphylococcus aureus were susceptible to BMY 28142 with MIC90=4·0 mg/l, while methicillin-resistant strains were generally resistant (MIC range 8–>32 mg/l).


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