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Journal of Antimicrobial Chemotherapy (1985) 16, 367-371
© 1985 The British Society for Antimicrobial Chemotherapy

research-article

The penetration of ceftriaxone into synovial fluid of the inflamed joint

John R. Morgan*, Alan Paull*, Margaret O'Sullivan* and Brian D. Williams{dagger}

*Departments of Medical Microbiology Heath Park, Cardiff CF4 4XN, Wales {dagger}Rheumatology, Welsh National School of Medicine Heath Park, Cardiff CF4 4XN, Wales

accepted 1 March 1985

Fifteen patients with acute exacerbation of rheumatoid arthritis each received a 1 g bolus intravenous injection of ceftriaxone. Serum and synovial fluid was sampled at intervals between 1 h and 24 h later and assayed for ceftriaxone. Synovial fluid leucocyte counts and albumin content were measured concomitantly. Detectable levels of ceftriaxone were found in synovial fluid and serum 24 h after injection. Synovial fluid ceftriaxone concentration ranged between 66% and 100% of the concomitant serum levels. No correlation was observed between synovial fluid ceftriaxone concentration and synovial fluid leucocyte count and albumin concentration.


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