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Journal of Antimicrobial Chemotherapy (1985) 16, 335-339
© 1985 The British Society for Antimicrobial Chemotherapy

research-article

Effects of clindamycin in combination with rifampicin on clindamycin-susceptible and clindamycin-resistant Staphylococcus aureus

Chatrchai Watanakunakorn

Infectious Disease Section, Department of Internal Medicine, St Elizabeth Hospital Medical Center Youngstown, Ohio 44501 The Northeastern Ohio Universities College of Medicine Rootstown, Ohio 44272, U.S.A.

accepted 12 March 1985

The effects of the combination of clindamycin and rifampicin against 21 strains of clindamycin-susceptible and 19 strains of clindamycin-resistant Staphylococcus aureus were studied by the time-kill method. For the clindamycin-susceptible strains, clindamycin prevented the re-growth of Staph. aureus in the presence of rifampicin. For the clindamycin-resistant Staph. aureus strains, indifference was demonstrated against the majority of strains, with only a few strains showing synergism or antagonism.


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