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Journal of Antimicrobial Chemotherapy (1985) 16, 315-325
© 1985 The British Society for Antimicrobial Chemotherapy

research-article

Cefpiramide: comparative in-vitro activity and ß-lactamase stability

A. L. Barrya, R. N. Jonesb, C. Thornsberryc, P. C. Fuchsd, L. W. Ayerse, T. L. Gavanf, E. H. Gerlachg and H. M. Sommersh

aThe Clinical Microbiology Institute Tualatin, Oregon 97062 bKaiser-Permanente Regional Laboratory Clackamas, Oregon 97015 cThe Centers for Disease Control Atlanta, Georgia 30333 dSt. Vincent Medical Center Portland, Oregon 97225 eThe Ohio State University Medical Center Columbus, Ohio 43210 fThe Cleveland Clinic Foundation Cleveland, Ohio 44106 gSt. Francis Medical Center Wichita, Kansas 67214 hNorthwestern Memorial Hospital Chicago, Illinois 60611, U.S.A.

accepted 25 March 1985

Cefpiramide is a new Pseudomonas-active cephalosporin with a broad spectrum of antibacterial activity. Like cefoperazone, cefpiramide was moderately susceptible to hydrolysis by a variety of ß-lactamases from Gram-negative bacilli. Tests with 6552 bacterial isolates in five separate medical centres documented cefpiramide's effectiveness against the more commonly encountered bacterial pathogens. Additional studies with 761 selected isolates, representing 35 species, demonstrated similarities between cefpiramide and cefoperazone: cefpiramide was more active against Acinetobacter spp. and Pseudomonas spp. Like most other cephalosporins, cefpiramide inhibited methicillin-susceptible staphylococci, non-enterococcal streptococci, Neisseria gonorrhoeae, N. meningitidis and ß-lactamase-negative Haemophilus influenzae. Cefpiramide was marginally active against Streptococcus faecalis (MIC 50, 80 mg/1).


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