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Journal of Antimicrobial Chemotherapy (1983) 12, 519-521
© 1983 The British Society for Antimicrobial Chemotherapy

research-article

The penetration of cefmenoxime into cerebrospinal fluid across non-inflamed meninges

Kenneth V. I. Rolston, Pranatharthi H. Chandrasekar, Bruce R. Smith and Jack L. LeFrock

Division of Infections Diseases and Clinical Microbiology, Hahnemann University Hospital Philadelphia, Pennsylvania 19102, U.S.A.

accepted 2 June 1983

Reprint requests to: Jack L. LeFrock, M.D., Chief, Division of Infectious Diseases and Clinical Microbiology, Hahnemann University Hospital, 230 North Broad Street, Philadelphia, Pennsylvania 19102. U.S.A.

The penetration of cefmenoxime, a newly-developed cephalosporin, across non-inflamed meninges was studied in 12 volunteers undergoing elective myelograms. Patients received 30 mg/kg of cefmenoxime intravenously every 6 h for three doses. Trough and peak serum levels were drawn just prior to and immediately after the last dose. CSF was obtained from 1 to 4 h after the administration of the last dose and a concomitant serum sample was also drawn. Cefmenoxime levels were determined by a microbiological assay and by high-performance liquid chromatography (HPLC). Cefmenoxime was detected in the CSF of all 12 patients and ranged between 0.15 and 1.4 mg/l.


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