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Journal of Antimicrobial Chemotherapy (1983) 12, 515-518
© 1983 The British Society for Antimicrobial Chemotherapy

research-article

Activity of trimethoprim (TMP), sulphamethoxazole (SMX) and the combination against Bacteroides fragilis group isolates

Gary L. Jackson-York, Brooks B. Gump and Dieter W. Gump

Infectious Disease Unit, Department of Medicine, University of Vermont College of Medicine Burlington, Vermont 05405, U.S.A

accepted 27 May 1983

The in-vitro efficacy of trimethoprim/sulphamethoxazole (TMP/SMX) was tested against 59 isolates belonging to the Bacteroides fragilis group of bacteria and was shown to be dependent upon the inoculum size. With an inoculum of 3 x 105 colony forming units (cfu), 98% of these isolates were susceptible to the combination, whereas with a higher inoculum of 106 cfu, 88% were susceptible. None of the isolates were susceptible to less than 2 mg/l of TMP, whereas 57 (97%) were susceptible to SMX at the lower inoculum and 21 (36%) at the higher inoculum. These data indicate that TMP/SMX has moderate activity against organisms of the Bact. fragilis group when tested at an inoculum of 106 cfu.


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