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Journal of Antimicrobial Chemotherapy (1983) 12, 451-458
© 1983 The British Society for Antimicrobial Chemotherapy

research-article

Frequency of ß-lactamases that are markedly active against carbenicillin in the Pseudomonas aeruginosa strains isolated in a Medical School Hospital

Michèle Jouvenot*, Patrice Bonin{dagger} and Yvon Michel-Briand{dagger}

*INSERM- U 198, Route de Dole 25000 Besançon Chateaufarine, France {dagger}Laboratoire de Bactériologie, Faculté de Médecine 25000 Besançon, France

accepted 11 May 1983

During one year, 71 carbenicillin-resistant Pseudomonas aeruginosa strains were isolated. The detection of the ß-lactamase activity in these strains was performed by the iodometric method. The ß-lactamases were found in 70% of the carbenicillin-resistant strains and were characterized by isoelectric focusing and by determination of substrate profiles.

Seventy-two per cent of the ß-lactamases tested focused in the same way as the PSE-1 type from strain PU21(RPL11). The determination of the substrate profiles by the acidimetric method showed that these enzymes had a high activity towards carbenicillin and that they can vary in their hydrolysis of cephalosporins. Such PSE-1 type ß-lactamases were found in gentamicin-tobramycin-resistant strains whereas other types of enzymes (PSE-4 enzymes and enzymes with pl 7.7) were found in strains sensitive to these antibiotics.


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